Cholinergic stimulation with pyridostigmine protects against exercise induced myocardial ischaemia
نویسندگان
چکیده
منابع مشابه
Cholinergic stimulation with pyridostigmine protects against exercise induced myocardial ischaemia.
OBJECTIVE To determine the acute effects of pyridostigmine bromide, a reversible cholinesterase inhibitor, during exercise in patients with coronary artery disease. DESIGN Double blind, randomised, placebo controlled, crossover study. SETTING Outpatients evaluated in an exercise test laboratory. PATIENTS 15 patients with exercise induced myocardial ischaemia. INTERVENTIONS Maximal cardi...
متن کاملCholinergic stimulation with pyridostigmine protects myocardial infarcted rats against ischemic-induced arrhythmias and preserves connexin43 protein.
We investigated the effects of acute pyridostigmine (PYR) treatment, an acetylcholinesterase inhibitor, on arterial pressure (AP), heart rate (HR), cardiac sympathovagal balance, and the incidence of arrhythmias during the first 4 h after myocardial infarction (MI) in anesthetized rats. Male Wistar rats were implanted with catheters into the femoral artery and vein for AP recordings and drug ad...
متن کاملEnhancement of Frequency Domain Indices of Heart Rate Variability by Cholinergic Stimulation with Pyridostigmine Bromide
Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...
متن کاملEnhancement of Frequency Domain Indices of Heart Rate Variability by Cholinergic Stimulation with Pyridostigmine Bromide
Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...
متن کاملExercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing.
BACKGROUND The objective of the study was to identify the parameter(s) of cardiopulmonary exercise testing (CPET) that can detect exercise-induced myocardial ischaemia (EIMI), and to determine its diagnostic accuracy for identifying patients with coronary artery disease (CAD). METHODS AND RESULTS We prospectively studied 202 consecutive patients (173 men, 29 women, mean age 55.7+/-10.8 years)...
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ژورنال
عنوان ژورنال: Heart
سال: 2004
ISSN: 1355-6037
DOI: 10.1136/hrt.2003.028167